Biopharmaceutics is the study of the fate of drugs in biological systems after administration (i.e., absorption, distribution, metabolism, and excretion; ADME) and its mechanisms. Pharmacokinetics is the science of the kinetics of drug ADME. The study of biopharmaceutics and pharmacokinetics is based on fundamental scientific principles and techniques developed in the fields of anatomy, physiology, biology, engineering mathematics, statistics, etc. Biopharmaceutics and pharmacokinetics provide the scientific basis for design and development of drug products and dosage regimens. In particular, scientists in the fields of biopharmaceutics and pharmacokinetics can collaborate closely with those of pharmaceutics, physical pharmacy, pharmacology, toxicology, clinical pharmacy, etc., and contribute eventually to the optimization of drug delivery and therapy. In our laboratory, we are mainly working on the following research topics by using various in vitro/in vivo experimental and in silico kinetic modeling approaches.
- Metabolizing enzymes- and transporters-mediated absorption and disposition of xenobiotics
- Drug interactions with drugs, functional foods, and natural products
- Bioanalytical method development
- Physiologically-based pharmacokinetic modeling & simulation
- Drug formulations for oral and transdermal bioavailability enhancement
For more detailed information, please refer to the following web links to the full list of our research achievements: